Reader in Immunity and Inflammation
Honorary Consultant Nephrologist
Director of Clinical Studies, Pembroke College
Research themes
Departments and Institutes
Research Interests
The Clatworthy lab is interested in understanding how B cell activation and IgG antibody effector function is regulated in different tissues, particularly in the kidney and the gut.
Current research questions:
- How can we regulate B cell activation and antibody generation in human disease?
- Which immune cells are capable of responding to IgG in the kidneys, and how is their position and function influenced by the kidney microenvironment.
- What role do IgG and FcgR play in the gastrointestinal tract?
- How does FcgR-crosslinking by IgG affect immune cell metabolism?
Keywordsantibodies ; B cells |
Key Publications
Selected References
Berry MR, Mathews RJ, Ferdinand JR, Jing C, Loudon KW, Wlodek E, Dennison TW, Kuper C, Neuhofer W, Clatworthy MR. Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone. Cell. 2017;170(5):860-74.
Clatworthy MR, Petri Aronin C, Matthews RJ, Morgan NY, Smith KGC, Germain RN. Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes. Nature Medicine. 2014;20(12):1458-63
Clatworthy MR, Watson CJ, Plotnek G, Bardsley V, Chaudhry AN, Bradley JA, Smith KG. B-cell-depleting induction therapy and acute cellular rejection. N Engl J Med. 2009;360(25):2683-5
