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Cambridge Cardiovascular


Laboratory Manager

Divisional Safety Officer


Key publications: 

Yu E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JC, Hurst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR: Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans. Circulation. 2013 Aug 13;128(7):702-12.

Gorenne I, Kumar S, Gray K, Figg N, Yu H, Mercer J, Bennett M: Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis. Circulation. 2013 Jan 22;127(3):386-96.

Mercer JR, Gray K, Figg N, Kumar S, Bennett MR: The methyl xanthine caffeine inhibits DNA damage signaling and reactive species and reduces atherosclerosis in ApoE(-/-) mice. Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2461-7.

Blackmore HL, Piekarz AV, Fernandez-Twinn DS, Mercer JR, Figg N, Bennett M, Ozanne SE: Poor maternal nutrition programmes a pro-atherosclerotic phenotype in ApoE-/- mice. Clin Sci (Lond). 2012 Aug 1;123(4):251-7.

Siggens L, Figg N, Bennett M, Foo R: Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1. FASEB J. 2012 May;26(5):2117-24.

Gaspar-Pereira S, Fullard N, Townsend PA, Banks PS, Ellis EL, Fox C, Maxwell AG, Murphy LB, Kirk A, Bauer R, Caamaño JH, Figg N, Foo RS, Mann J, Mann DA, Oakley F: The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis. Am J Pathol. 2012 Mar;180(3):929-39.

Mercer JR, Yu E, Figg N, Cheng KK, Prime TA, Griffin JL, Masoodi M, Vidal-Puig A, Murphy MP, Bennett MR: The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice. Free Radic Biol Med. 2012 Mar 1;52(5):841-9.

Yu H, Clarke MC, Figg N, Littlewood TD, Bennett MR: Smooth muscle cell apoptosis promotes vessel remodeling and repair via activation of cell migration, proliferation, and collagen synthesis. Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2402-9.

Yu H, Stoneman V, Clarke M, Figg N, Xin HB, Kotlikoff M, Littlewood T, Bennett M: Bone marrow-derived smooth muscle-like cells are infrequent in advanced primary atherosclerotic plaques but promote atherosclerosis. Arterioscler Thromb Vasc Biol. 2011 Jun;31(6):1291-9.

Glover M, Mercier Zuber A, Figg N, O'Shaughnessy KM: The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4. Can J Physiol Pharmacol. 2010 Oct;88(10):986-95.

Mercer JR, Cheng KK, Figg N, Gorenne I, Mahmoudi M, Griffin J, Vidal-Puig A, Logan A, Murphy MP, Bennett M: DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res. 2010 Oct 15;107(8):1021-31.