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Cambridge Cardiovascular

Tissue Engineering
Scaffolds and 3D Environments


Ice templating 3D environments for the control of tissue growth

We are using ice templating techniques to create materials that mimic the complex orientational and spatial anisotropy of natural tissue, and that impart defined biochemical and mechanical cues.  This is enabling us to develop bespoke cellular environments for clinical contexts including cardiac, dental and orthopaedic repair, cancer research and diagnosis, and blood cell production.

Biodegradable polymers and composites

We are exploring the intricate temporal and spatial relationships between the processing and morphology of the material, the diffusion rates of water, drug and degradation products, the degradation rate of the polymer and ultimate properties. An understanding of these factors allows informed device design. Our study of composites ranges from the micro co-continuous to the nano-scale, for orthoapedic and other tissue repair.

Biostable implants

In many surgical applications, the implant material must not change over time within the challenging environment of the body.  Issues we addressing include those spinal and cardiac surgery.

Drug delivery and pharmaceutics

We have interests relating to drug delivery to the body including drug polymorphism, tablet design and inhalation delivery systems.


Key publications: 

Please follow the link to PubMed for a full list of publications.

Selecting the correct cellular model for assessing of the biological response of collagen-based biomaterials. Davidenko N, Hamaia S, Bax DV, Malcor JD, Schuster CF, Gullberg D, Farndale RW, Best SM, Cameron RE. Acta Biomater. 2018 Jan;65:88-101.

Fundamental insight into the effect of carbodiimide crosslinking on cellular recognition of collagen-based scaffolds. Bax DV, Davidenko N, Gullberg D, Hamaia SW, Farndale RW, Best SM, Cameron RE. Acta Biomater. 2017 Feb;49:218-234.

Development of three-dimensional collagen scaffolds with controlled architecture for cell migration studies using breast cancer cell lines. Campbell JJ, Husmann A, Hume RD, Watson CJ, Cameron RE. Biomaterials. 2017 Jan;114:34-43.

The effect of the type of HA on the degradation of PLGA/HA composites. Naik A, Shepherd DV, Shepherd JH, Best SM, Cameron RE. Mater Sci Eng C Mater Biol Appl. 2017 Jan 1;70(Pt 1):824-831.

The effect of particle size on the in vivo degradation of poly(d,l-lactide-co-glycolide)/α-tricalcium phosphate micro- and nanocomposites. Bennett SM, Arumugam M, Wilberforce S, Enea D, Rushton N, Zhang XC, Best SM, Cameron RE, Brooks RA. Acta Biomater. 2016 Nov;45:340-348.

Evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry. Davidenko N, Schuster CF, Bax DV, Farndale RW, Hamaia S, Best SM, Cameron RE. J Mater Sci Mater Med. 2016 Oct;27(10):148.

Structural determinants of hydration, mechanics and fluid flow in freeze-dried collagen scaffolds. Offeddu GS, Ashworth JC, Cameron RE, Oyen ML. Acta Biomater. 2016 Sep 1;41:193-203.

Parameterizing the Transport Pathways for Cell Invasion in Complex Scaffold Architectures. Ashworth JC, Mehr M, Buxton PG, Best SM, Cameron RE. Tissue Eng Part C Methods. 2016 May;22(5):409-17.

The synthesis and coupling of photoreactive collagen-based peptides to restore integrin reactivity to an inert substrate, chemically-crosslinked collagen. Malcor JD, Bax D, Hamaia SW, Davidenko N, Best SM, Cameron RE, Farndale RW, Bihan D. Biomaterials. 2016 Apr;85:65-77.

Optimisation of UV irradiation as a binding site conserving method for crosslinking collagen-based scaffolds. Davidenko N, Bax DV, Schuster CF, Farndale RW, Hamaia SW, Best SM, Cameron RE. J Mater Sci Mater Med. 2016 Jan;27(1):14.

Professor of Materials Science
Joint Head of Department in the Department of Materials Science


Person keywords: 
tissue engineering
biodegradable polymers
regenerative medicine
collagen scaffold