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Professor Serena Best

Professor Serena Best

Professor of Materials Science

Collagen scaffolds

Bioactive and bioresorbable composites for tissue engineering


Office Phone: 01223 334307

Research Interests

I direct the Cambridge Centre for Medical Materials together with Prof Ruth Cameron. My research aims to expand the range and performance of bioactive scaffolds in clinical applications.

Bioactive and bioresorbable composites for tissue engineering

We aim to develop composites with properties tailored to their specific application. The organic matrices comprise a range of biodegradable polymers. The fillers include bioactive ceramics, glasses and glass ceramics. Filler particles with a variety of morphologies and dimensions are being investigated along with the refinement of techniques to produce porous structures over a range of different densities and with controlled pore shape and size.

Collagen Scaffolds

The design of porous architectures with controlled mechanical properties and surface chemistries is essential to optimise the repair and reconstruction soft tissues. Applications for collagen-GAG based scaffolds include dental materials, heart tissue repair and the production of platelets. We are seeking to gain fundamental understanding of the effects of production parameters and the effects of biochemical surface modification on the biological mechanisms of action, to produce tailor-made three dimensional porous structures.

Keywords

collagen scaffold ; tissue engineering ; regenerative medicine

Key Publications

Please follow the link to PubMed for a full list of publications.

Selecting the correct cellular model for assessing of the biological response of collagen-based biomaterials. Davidenko N, Hamaia S, Bax DV, Malcor JD, Schuster CF, Gullberg D, Farndale RW, Best SM, Cameron RE. Acta Biomater. 2018 Jan;65:88-101.

Fundamental insight into the effect of carbodiimide crosslinking on cellular recognition of collagen-based scaffolds. Bax DV, Davidenko N, Gullberg D, Hamaia SW, Farndale RW, Best SM, Cameron RE. Acta Biomater. 2017 Feb;49:218-234.

The effect of the type of HA on the degradation of PLGA/HA composites. Naik A, Shepherd DV, Shepherd JH, Best SM, Cameron RE. Mater Sci Eng C Mater Biol Appl. 2017 Jan 1;70(Pt 1):824-831.

The effect of particle size on the in vivo degradation of poly(d,l-lactide-co-glycolide)/α-tricalcium phosphate micro- and nanocomposites. Bennett SM, Arumugam M, Wilberforce S, Enea D, Rushton N, Zhang XC, Best SM, Cameron RE, Brooks RA. Acta Biomater. 2016 Nov;45:340-348.

Evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry. Davidenko N, Schuster CF, Bax DV, Farndale RW, Hamaia S, Best SM, Cameron RE. J Mater Sci Mater Med. 2016 Oct;27(10):148.

Parameterizing the Transport Pathways for Cell Invasion in Complex Scaffold Architectures. Ashworth JC, Mehr M, Buxton PG, Best SM, Cameron RE. Tissue Eng Part C Methods. 2016 May;22(5):409-17.

The synthesis and coupling of photoreactive collagen-based peptides to restore integrin reactivity to an inert substrate, chemically-crosslinked collagen. Malcor JD, Bax D, Hamaia SW, Davidenko N, Best SM, Cameron RE, Farndale RW, Bihan D. Biomaterials. 2016 Apr;85:65-77.

Optimisation of UV irradiation as a binding site conserving method for crosslinking collagen-based scaffolds. Davidenko N, Bax DV, Schuster CF, Farndale RW, Hamaia SW, Best SM, Cameron RE. J Mater Sci Mater Med. 2016 Jan;27(1):14.

Altering crystal growth and annealing in ice-templated scaffolds. Pawelec KM, Husmann A, Best SM, Cameron RE. J Mater Sci. 2015;50(23):7537-7543.

Control of crosslinking for tailoring collagen-based scaffolds stability and mechanics. Davidenko N, Schuster CF, Bax DV, Raynal N, Farndale RW, Best SM, Cameron RE. Acta Biomater. 2015 Oct;25:131-42.

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