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Vera Graup

Vera Graup

BHF Cambridge Centre of Excellence PhD Student


Research Interests

Supervisor: Prof Ruth Cameron

Title: 3-dimensional design of collagen scaffolds for the purpose of cardiac regeneration

Abstract: Over the past decades, biomaterials have emerged as potential treatment strategies for local tissue repair and regeneration, combining a materials and cell based approach.

Using a combination of techniques, such as crystal templating and cross-linking, collagen scaffolds will be designed to replicate the three dimensional pore structure and mechanical properties of the human heart. Such scaffolds (‘cardiac patches’) can be used to deliver stem cells and drugs directly to the site of injury.

In collaboration with the Laboratory for Regenerative Medicine (Dr Sanjay Sinha), I will test scaffolds of varying designs to assess their suitability to support the maintenance of the physiological phenotype of relevant cardiac cell types.

 

Keywords

crystal templating ; collagen ; cell-material interactions ; polymer degradation ; regenerative medicine

Key Publications

Vera Graup, Natalia Davidenko, Maria Colzani, Sanjay Sinha, Serena M Best, Ruth E Cameron; Material and Surface-structure modification of collagen scaffolds for cardiac tissue engineering. 28th Annual Conference of the European Society for Biomaterials; Athens, Sept 2017

Vera Graup, Gui Zhen Teoh, Wenhui Song; Electrospun biodegradable polyurethane nanocomposite scaffolds for cardiac regeneration 28th Annual Conference of the European Society for Biomaterials; Athens, Sept 2017

Vera Graup, Natalia Davidenko, Maria Colzani, Sanjay Sinha, Serena M Best, Ruth E Cameron; Design considerations for the creation of a cardiac patch. 2017 Armourers and Brasiers's Forum; Cambridge, June 2017

Vera Graup 3D design of ultra-porous collagen scaffolds for the purpose of cardiac regeneration. EBI-Sanger-Cambridge PhD Symposium; Cambridge, February 2017

Vera Graup Designing scaffold biomaterials for heart tissue repair. BHF Cardiovascular Early Careers Event; Cambridge, September 2016

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