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Dr Colin E. Evans

Research Interests

Dr Evans studies mechanisms that regulate the associations between hypoxia, thrombosis, and other vascular diseases. Thrombi are more likely to form in cancer patients compared with healthy people, and blood flow to newly formed thrombi and tumours is restricted. Dr Evans is investigating whether hypoxia-inducible factors (HIFs) in cells within the tumour microenvironment stimulate thrombosis and, conversely, whether HIFs in cells within and around the thrombus stimulate tumour progression. A better understanding of the mechanisms that control thrombosis-associated cancer progression may lead to the development of novel treatments for patients with Trousseau's Syndrome (i.e. hypercoagulable malignancy).

Dr Evans’ research also aims to identify mechanisms that control thrombus formation and subsequent resolution, which could lead to the development of new therapies that reduce the incidence of deep vein thrombosis or the risk of pulmonary embolism. In related work, Colin is aiming to determine whether the vascular response to thrombosis-induced hypoxia regulates pulmonary function and hypercoagulation during sepsis. 

Keywords

cancer ; thrombosis ; vascular biology ; hypoxia ; cardiovascular disease ; cardiovascular physiology ; Trousseau Syndrome ; coagulation factors ; angiogenesis

Key Publications

Evans CE, Zhao YY. Impact of thrombosis on pulmonary endothelial injury and repair following sepsisAmerican Journal of Physiology - Lung Cellular and Molecular Physiology, 2017, 312(4), L441-51.

Evans CE, Palazon A, Sim J, Tyrakis PA, Prodger A, Lu X, Chan S, Bendahl P-O, Belting M, Von Euler L, Rundqvist H, Johnson RS, Branco C. Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesisBiology Open, 2017, 6, 688-97.

Evans CE, Bendahl P-O, Belting M, Branco C, Johnson RS. Diverse roles of cell-specific HIF1 in cancer-associated hypercoagulation. Blood, 2016, 127(10), 1355-60.

Grover SP, Evans CE (joint first author), Patel AS, Modarai M, Saha P, Smith A. Assessment of venous thrombosis in animal models. Arteriosclerosis, Thrombosis, and Vascular Biology, 2016, 36(2), 245-52.

Evans CE, Grover SP, Jenkins J, Saha P, Patel A, Patel AS, Lyons OT, Modarai B, Smith A. Anti-angiogenic therapy inhibits venous thrombus resolutionArteriosclerosis, Thrombosis, and Vascular Biology, 2014, 34(3), 565-70.

Evans CE, Mattock K, Humphries J, Saha P, Ahmad A, Waltham M, Patel A, Modarai B, Porter L, Premaratne S, Smith A. Techniques of assessing hypoxia at the bench and bedside. Angiogenesis, 2011, 14(2), 119-24.

Evans CE, Humphries J, Mattock K, Waltham M, Wadoodi A, Saha P, Modarai B, Maxwell P, Smith A. Hypoxia and upregulation of hypoxia-inducible factor 1 alpha stimulate venous thrombus recanalisation. Arteriosclerosis, Thrombosis, and Vascular Biology, 2010, 30, 2443-51.

For extended list please see the following link to Pubmed.

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