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Cambridge Cardiovascular



Isuru was recently interviewed for our 'Spotlight on...' article series.

The Glycoprotein VI Receptor in Atrial Fibrillation & ThromboEmbolism

(GRAFITE) study will investigate the involvement of platelets in blood clot formation. The research will be carried out on blood samples of individuals admitted to Cambridge University Hospitals with either atrial fibrillation or venous thromboembolism.

We will specifically look at any genetic variances that cause blood clots, as well as investigating the role of the platelet receptor glycoprotein VI in blood clot formation and whether its inhibition could lead to arresting the platelet cascade at an earlier stage and reduce the size of the blood clot.


Key publications: 

Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation. Induruwa I, Moroi M, Bonna A, Malcor JD, Howes JM, Warburton EA, Farndale RW, Jung SM. J Thromb Haemost. 2018 Feb;16(2):389-404.

The increasing burden of atrial fibrillation in acute medical admissions, an opportunity to optimise stroke prevention. Induruwa I, Amis E, Hannon N, Khadjooi K. J R Coll Physicians Edinb. 2017 Dec;47(4):331-335.

Clinical frailty is independently associated with non-prescription of anticoagulants in older patients with atrial fibrillation. Induruwa I, Evans NR, Aziz A, Reddy S, Khadjooi K, Romero-Ortuno R. Geriatr Gerontol Int. 2017 Nov;17(11):2178-2183.

Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke. Induruwa I, Jung SM, Warburton EA. Int J Stroke. 2016 Aug;11(6):618-25.