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Jessica Beeson

Jessica Beeson

BHF 4-Year Programme PhD Student

Research Interests

Supervisor: Prof Susan Ozanne

Title: Investigating whether regular exercise in obese mothers can prevent poor long-term cardiovascular health of offspring

Abstract: There has been an increase in obesity amongst women of childbearing age; this is a growing threat to the health of the offspring due to the long-term detrimental effects caused by early life exposure to maternal obesity. Studies have shown that individuals from obese mothers are at increased risk of premature death by cardiovascular disease (CVD). There is good evidence to suggest that these effects are mediated by non-genetic “programmed” mechanisms.

This study aims to investigate the effect of maternal exercise as a potential intervention, on the cardiovascular health of the offspring.

Using a well-characterised mouse model the study will assess immediate and long-term protective effects of exercise on the cardiovascular health of the offspring and explore the translational potential for circulating microRNAs to act as biomarkers for CVD risk.

An evidence-based intervention is needed to prevent the propagation of obesity and CVD to the next generation.


  • Cambridge Metabolic Network Conference 2015: Why is exercise good for us? - complementing genetics for better metabolic regulation.


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