skip to primary navigationskip to content
 

Mary Goodwin

Mary Goodwin

PhD Student


Research Interests

Supervisor: Dr Alessandra Granata and Prof Hugh Markus

Title: Developing human induced pluripotent stem cell (hiPSC) models of cerebral small vessel disease from skin biopsy tissue of patients with monogenic forms of SVD.

Abstract:

Cerebral Small Vessel Disease (SVD) is a major contributor to stroke and dementia worldwide, but little is known about the mechanisms that cause or propagate the disease. We are aiming to devise a 3D in vitro model of the blood-brain barrier to model SVD using patient derived iPSCs. These iPSCs will be differentiated into 3 different cells types: brain microvascular endothelial cells, pericytes and astrocytes. The resulting 3D triple co-culture model will enable us to elucidate the mechanism behind SVD pathophysiology such as the series of events leading to increased permeability of the blood-brain barrier. We hope that this knowledge will lead to the advent of new therapies to prevent the debilitating effects of SVD.

Cambridge Cardiovascular logo - transparent

Logo design by Dr Ana-Mishel Spiroski and Dr Sarah Morgan.

 

We connect cardiovascular researchers in Cambridge.

Please follow us on Twitter for local news about research, events, funding calls, and open positions.

For inquiries about our research or the website, please contact Dr Katja Kivinen.