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Dr Meritxell Nus

Dr Meritxell Nus

Senior Research Associate

BHF Basic Science Intermediate Fellow

Meritxell Nus is accepting applications for PhD students.

Research themes

Vascular Medicine:

Research Interests

I am interested in the molecular pathways that drive the activation of the atheroprotective programme in adaptive immune cells in response to a high cholesterol diet.

Lab Members

James Harrison


T follicular helper cells ; high cholesterol diet ; marginal zone B cells ; atherosclerosis ; notch signalling pathway


Collaborators outside this directory

Key Publications

  1. Nus M, Sage AP, LuY, Masters L, LamBYH, NewlandS, TsiantoulasD, RaffortJ, Finigan A, KittL, FiggN, SchirmbeckR, KneillingM, YeoGSH, BinderC, de la PompaJL, Mallat Z. Marginal zone B cells control follicular helper T cell response to high cholesterol diet (Nat Med 2017; doi:10.1038/nm.4315)
  2. Nus M, Martínez-Poveda B, Macgrogan D, Chevre R, D´Amato G, Sbroggio M, Rodriguez C, Martínez-Gonzalez J, Vicente A, Hidalgo A, de la Pompa JL. Endothelial Notch signaling is required for the NF-kB driven inflammatory response in atherosclerosis. Cardiovasc Res 2016; epub August.
  3. Sage AP, Nus M, Baker L, Finigan A, Masters L, Mallat Z. Regulatory B cell-specific interleukin-10 is dispensable for atherosclerosis development in mice. Arterioscler Thromb Vasc Biol 2015;35:1770-3.
  4. Nus M, MacGrogan D, Martínez-Poveda B, Benito Y, Casanova JC, Fernández-Avilés F, Bermejo J, de la Pompa JL. Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL.  Arterioscler Thromb Vasc Biol  2011; 31:1580-8
  5. Nus M, Sánchez-Muniz FJ, Sánchez-Montero JM. A new method for the determination of arylesterase activity in human serum using simulated body fluids. Atherosclerosis 2006; 188:155-159.
  6. Nus, M., Basatemur, G., Galan, M., Cros-Brunsó, L., Zhao, T., Masters, L., Harrison, J., et al. NR4A1 deletion in marginal zone B cells exacerbates atherosclerosis in mice. Arteriosclerosis, Thrombosis and Vascular Biology 2020

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