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Dr Michael Inouye

Dr Michael Inouye

Principal Research Associate

Turing Fellow

Director, Cambridge Baker Systems Genomics Initiative


Research themes

Population Sciences:

Research Interests

I have a joint appointment between the Baker Heart & Diabetes Institute and the Department of Public Health and Primary Care at Cambridge University, where I lead the Cambridge Baker Systems Genomics Initiative.

My group focuses on (i) building genomic risk scores, alone or in combination with established risk factors, to potentially guide early risk screening and prevention of disease, and (ii) integrative analysis of multiple omics data to understand how genomic risk propagates through biomolecular networks, and which potential therapeutic targets, to cause disease.

Keywords

cardiovascular genomics ; functional genomics

Collaborators

Key Publications

Updated list of publications can be found on PubMed.

Inouye M*, Abraham G*, ... [22 authors] ..., Samani NJ*. Genomic risk prediction of coronary artery disease in 480,000 adults: Implications for primary prevention. Journal of the American College of Cardiology 2018. 72(16):1883-93.

Teo SM, ... [16 authors] ..., Holt KE*, Inouye M*. Airway microbiota dynamics identify a critical window for interplay of pathogenic bacteria and allergy in childhood respiratory disease. Cell Host & Microbe 2018. 24(3):341-352.

Holt KE, ... [14 co-authors] ..., Inouye M, Caws M, Dunstan SJ. Genomic analysis of Mycobacterium tuberculosis reveals complex etiology of tuberculosis in Vietnam including frequent introduction and transmission of Beijing lineage and positive selection for EsxW Beijing variant. Nature Genetics 2018. in press.

Nath AP, ... [24 co-authors] ..., Inouye M. An interaction map of circulating metabolites, immune gene networks and their genetic regulation. Genome Biology 2017. 13(6):e1006328.

Byars SG, ... [6 co-authors] ..., Inouye M. Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleitropy. PLOS Genetics 2017. 13(6)e1006328.

Ritchie SC, ... [4 co-authors] ..., Inouye M. A permutation-based approach to replication and preservation of network modules in large datasets. Cell Systems 2016. 3(1):71-82.

Abraham G, ... [12 co-authors] ..., Samani NJ*, Salomaa V*, Ripatti S*, Inouye M*. Genomic prediction of coronary heart disease. European Heart Journal 2016. ehw450.

Teo SM Inouye M*. The infant airway microbiome impacts severity of lower respiratory infection and risk of asthma development. Cell Host & Microbe 2015. 17:1-12.

Ritchie SC, ... [20 co-authors] ..., Kettunen J*, Inouye M*. The biomarker GlycA is associated with chronic inflammation and predicts long-term risk of severe infection. Cell Systems 2015. 1(4):293-301.

Inouye M, ... [6 co-authors] ..., Holt KE. SRST2: Rapid genomic surveillance for public health and hospital microbiology labs. Genome Medicine 2014. 6:90.

Abraham G, ... [4 co-authors] ..., Inouye M. Accurate and robust genomic prediction of celiac disease using statistical learning. PLOS Genetics 2014. 10(2): e1004137.

Inouye M, ... [18 co-authors] ..., de Bakker PIW. Novel loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. PLOS Genetics 2012. 8(8):e1002907.

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