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Dr Sarah Teichmann

Research themes

Functional Genomics:

Research Interests

My group studies the principles of protein structure evolution, higher order protein structure and protein folding, and the principles underlying protein complex formation and organization.

We have a longstanding interest in understanding gene expression regulation, and we use mouse T helper cells as a model of cell differentiation in our laboratories at the Wellcome Trust Sanger Institute.


single-cell RNA sequencing ; protein structure ; RNA sequencing ; protein evolution ; protein biochemistry

Key Publications

Structural and evolutionary versatility in protein complexes with uneven stoichiometry. Marsh JA, Rees HA, Ahnert SE, Teichmann SA. Nat Commun. 2015 Mar 16;6:6394. doi: 10.1038/ncomms7394.

Computational and analytical challenges in single-cell transcriptomics. Stegle O, Teichmann SA, Marioni JC. Nat Rev Genet. 2015 Mar;16(3):133-45. doi: 10.1038/nrg3833. Epub 2015 Jan 28. Review.

Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells. Buettner F, Natarajan KN, Casale FP, Proserpio V, Scialdone A, Theis FJ, Teichmann SA, Marioni JC, Stegle O. Nat Biotechnol. 2015 Feb;33(2):155-60. doi: 10.1038/nbt.3102. Epub 2015 Jan 19.

Evolution of oligomeric state through allosteric pathways that mimic ligand binding. Perica T, Kondo Y, Tiwari SP, McLaughlin SH, Kemplen KR, Zhang X, Steward A, Reuter N, Clarke J, Teichmann SA. Science. 2014 Dec 19;346(6216):1254346.

Structure, Dynamics, Assembly, and Evolution of Protein Complexes. Marsh JA, Teichmann SA. Annu Rev Biochem. 2014 Dec 8.

Protein flexibility facilitates quaternary structure assembly and evolution. Marsh JA, Teichmann SA. PLoS Biol. 2014 May 27;12(5):e1001870.

Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis. Mahata B, Zhang X, Kolodziejczyk AA, Proserpio V, Haim-Vilmovsky L, Taylor AE, Hebenstreit D, Dingler FA, Moignard V, Göttgens B, Arlt W, McKenzie AN, Teichmann SA. Cell Rep. 2014 May 22;7(4):1130-42.

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Feig C, Jones JO, Kraman M, Wells RJ, Deonarine A, Chan DS, Connell CM, Roberts EW, Zhao Q, Caballero OL, Teichmann SA, Janowitz T, Jodrell DI, Tuveson DA, Fearon DT. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20212-7.

Parallel dynamics and evolution: Protein conformational fluctuations and assembly reflect evolutionary changes in sequence and structure. Marsh JA, Teichmann SA. Bioessays. 2014 Feb;36(2):209-18.

Accounting for technical noise in single-cell RNA-seq experiments. Brennecke P, Anders S, Kim JK, Kołodziejczyk AA, Zhang X, Proserpio V, Baying B, Benes V, Teichmann SA, Marioni JC, Heisler MG. Nat Methods. 2013 Nov;10(11):1093-5.

Evolution of protein structures and interactions from the perspective of residue contact networks. Zhang X, Perica T, Teichmann SA. Curr Opin Struct Biol. 2013 Dec;23(6):954-63.

The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes. Hall Z, Hernández H, Marsh JA, Teichmann SA, Robinson CV. Structure. 2013 Aug 6;21(8):1325-37.

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia. Roberts EW, Deonarine A, Jones JO, Denton AE, Feig C, Lyons SK, Espeli M, Kraman M, McKenna B, Wells RJ, Zhao Q, Caballero OL, Larder R, Coll AP, O'Rahilly S, Brindle KM, Teichmann SA, Tuveson DA, Fearon DT. J Exp Med. 2013 Jun 3;210(6):1137-51.

Protein complexes are under evolutionary selection to assemble via ordered pathways. Marsh JA, Hernández H, Hall Z, Ahnert SE, Perica T, Robinson CV, Teichmann SA. Cell. 2013 Apr 11;153(2):461-70.

More publications available through PubMed.

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