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Cambridge Cardiovascular



My research focuses on megakaryopoiesis and platelet biogenesis from human pluripotent stem cells. We have developed a unique forward programming protocol for efficient production of these cells in vitro which opens new avenues for biological models of normal and pathological thrombopoiesis, as well as for clinical application in transfusion medicine.

My work is developing to the study of molecular mechanisms controlling the megakaryocyte differentiation output from different stem cell sources and advancing the forward programming approach towards clinical application.



Key publications: 

Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming. Moreau T, Evans AL, Vasquez L, Tijssen MR, Yan Y, Trotter MW, Howard D, Colzani M, Arumugam M, Wu WH, Dalby A, Lampela R, Bouet G, Hobbs CM, Pask DC, Payne H, Ponomaryov T, Brill A, Soranzo N, Ouwehand WH, Pedersen RA, Ghevaert C. Nat Commun. 2016 Apr 7;7:11208.

Brain-derived Neurotrophic Factor in Megakaryocytes. Chacón-Fernández P, Säuberli K, Colzani M, Moreau T, Ghevaert C, Barde YA. J Biol Chem. 2016 May 6;291(19):9872-81.

NANOG and CDX2 pattern distinct subtypes of human mesoderm during exit from pluripotency. Mendjan S, Mascetti VL, Ortmann D, Ortiz M, Karjosukarso DW, Ng Y, Moreau T, Pedersen RA. Cell Stem Cell. 2014 Sep 4;15(3):310-25.

Research Associate
Dr Thomas  Moreau


Person keywords: 
Pluripotent stem cells
transfusion medicine