Dr William Astle

  • Senior Lecturer in Biostatistics
Dr William Astle

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Research

I am interested in the application and development of statistical and epidemiological methods to understand haematological risk factors for cardiovascular diseases. My work covers genome-wide association studies, metabonomics, the analysis of NMR spectra and RNA-Seq data sets, and gene expression studies.

My current focus is on the analysis of the blood trait phenotypes measured in the UK Biobank and INTERVAL studies. These collaborations with colleagues from the CEU, Department of Haematology, and the Wellcome Trust Sanger Institute, had led to a 10-fold increase in the number of genetic loci known to modulate properties of the blood, and has identified reticulocyte count as a potential risk factor for coronary heart disease.

Collaborators

  1. Dr Ernest Turro

    Dr Ernest Turro

    • Senior Research Associate
  2. Dr Kate Downes

    Dr Kate Downes

    • Lead Scientist for Rare and Inherited Disease, NHS East Genomic Laboratory Hub, Cambridge University Hospitals
  3. Dr Mattia Frontini

    Dr Mattia Frontini

    • BHF Senior Basic Science Research Fellow
  4. Professor Adam Butterworth

    Professor Adam Butterworth

    • Professor of Molecular Epidemiology
  5. Professor John Danesh

    Professor John Danesh

    • BHF Professor of Epidemiology and Medicine
  6. Professor Nicole Soranzo

    Professor Nicole Soranzo

    • Professor of Human Genetics, School of Clinical Medicine, at the University of Cambridge
  7. Professor Sylvia Richardson

    Professor Sylvia Richardson

    • Director of the MRC Biostatistics Unit
  8. Professor Willem Ouwehand

    Professor Willem Ouwehand

    • Emeritus Professor of Experimental Haematology, Director of Research