Research
I lead the research group for modelling cerebrovascular diseases using patient-derived induced pluripotent stem cells (iPSC). I am based at the Clifford Allbutt Building, Central Biomedical Campus, Addenbrooke’s Site and am part of the Stroke Research Group of Professor Hugh Markus, in the department of Clinical Neurosciences.
My main research interest is to develop iPSC-based model system for genetic forms of cerebral small vessel diseases (SVD), exploiting findings from genome wide association studies (GWAS) and whole genome sequencing studies in ischaemic stroke. We believe that iPSC-derived models can be used to uncover disease mechanisms and to identify new treatments for SVD.
Publications
Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM. Clin Sci (Lond). 2018 Apr 30;132(8):851-868.
An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death. Granata A, Serrano F, Bernard WG, McNamara M, Low L, Sastry P, Sinha S. Nat Genet. 2017 Jan;49(1):97-109.
Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3. Granata A, Bernard WG, Zhao N, Mccafferty J, Lilly B, Sinha S. Stem Cells Dev. 2015 Apr 1;24(7):846-56.
Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application. Sinha S, Iyer D, Granata A. Cell Mol Life Sci. 2014 Jun;71(12):2271-88.
