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Professor Hugh Markus

Professor Hugh Markus

Professor of Stroke Medicine

Honorary Consultant Neurologist

Research Interests

Using genetic and imaging techniques to understand the pathogenesis of ischaemic stroke

I use molecular genetic and neuroimaging (MRI and Transcranial Doppler) techniques to investigate the pathogenesis of, and develop treatments for, cerebrovascular disease.

A particular interest is in cerebral small vessel disease, a major cause of stroke and the major cause of vascular cognitive impairment; here we are studying genetic determinants (for both monogenic and polygenic disease), the mechanisms of cognitive decline using advanced multimodal MRI, and evaluating new therapeutic approaches.

I am involved in a number of international studies of stroke genetics including the WTCCC2 ischaemic stroke study and the International Stroke Genetics Consortium. I run a National clinical referral service for patients with the monogenic from of stroke CADASIL.


stroke ; genetics ; neuroimaging


  • Stroke

Key Publications

Most recent publications are listed on PubMed.

Oxidative phosphorylation and lacunar stroke: Genome-wide enrichment analysis of common variants. Traylor M, Anderson CD, Hurford R, Bevan S, Markus HS. Neurology. 2016 Jan 12;86(2):141-5.

Genetic Architecture of Lacunar Stroke. Traylor M, Bevan S, Baron JC, Hassan A, Lewis CM, Markus HS. Stroke. 2015 Sep;46(9):2407-12.

Mechanisms and treatment of ischaemic stroke--insights from genetic associations. Markus HS, Bevan S. Nat Rev Neurol. 2014 Dec;10(12):723-30.

A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. Traylor M, Mäkelä KM, Kilarski LL, Holliday EG, Devan WJ, Nalls MA, Wiggins KL, Zhao W, Cheng YC, Achterberg S, Malik R, Sudlow C, Bevan S, Raitoharju E; METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2), Oksala N, Thijs V, Lemmens R, Lindgren A, Slowik A, Maguire JM, Walters M, Algra A, Sharma P, Attia JR, Boncoraglio GB, Rothwell PM, de Bakker PI, Bis JC, Saleheen D, Kittner SJ, Mitchell BD, Rosand J, Meschia JF, Levi C, Dichgans M, Lehtimäki T, Lewis CM, Markus HS. PLoS Genet. 2014 Jul 31;10(7):e1004469.

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