Research
Arterial Haemodynamics and Experimental Medicine
My research focuses on understanding the biological pathways underlying systemic hypertension and arteriosclerosis, with a strong emphasis on basic physiology, experimental/translational medicine and early phase interventional clinical trials. Current major research projects include:
- The clinical value of novel haemodynamic biomarkers
- Assessing vascular inflammation in COPD and its importance
- The role of glycosaminoglycans in blood pressure and aortic stiffness regulation
- Developing non-invasive imaging for vascular inflammation; and calcification
- The impact of cardiovascular risk factors, and novel drugs on nitric oxide production and endothelial function
- Expression profiling of human aortae to identify novel stiffening candidates.
My group has expertise in vascular physiology/pharmacology, hypertension, endothelial biology and trial design. We have strong links with the Cambridge PhD and MPhil training programme in Translational Medicine and Therapeutics, and with several major pharmaceutical and device companies. I led the establishment of the Cambridge Clinical Trials Unit, which recently received NIHR accreditation. I have active collaborations with biomedical engineering, matrix biology, chemistry, and imaging in Cambridge; and external collaborations with the Universities of Cardiff, Manchester, Kings College London, Royal Brompton Hospital, and McQuarrie (Australia) and Zurich (Switzerland). My group also has developed collaborative partnerships with a number of Pharmaceutical Companies and Device Manufactures.
Publications
Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial. Gajendragadkar PR, Hubsch A, Mäki-Petäjä KM, Serg M, Wilkinson IB, Cheriyan J. PLoS One. 2014 Jun 9;9(6):e99070.
Evaluating the role of inflammation in chronic airways disease: the ERICA study. Mohan D, Gale NS, McEniery CM, Bolton CE, Cockcroft JR, MacNee W, Fuld J, Lomas DA, Calverley PM, Shale DJ, Miller BE, Wilkinson IB, Tal-Singer R, Polkey MI; ERICA Consortium. COPD. 2014 Sep;11(5):552-9.
S-Nitrosoglutathione improves haemodynamics in early-onset pre-eclampsia. Everett TR, Wilkinson IB, Mahendru AA, McEniery CM, Garner SF, Goodall AH, Lees CC. Br J Clin Pharmacol. 2014 Sep;78(3):660-9.
Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease. Fisk M, Gajendragadkar PR, Mäki-Petäjä KM, Wilkinson IB, Cheriyan J. Am J Cardiovasc Drugs. 2014 Jun;14(3):155-65.
Pre-dialysis systolic blood pressure-variability is independently associated with all-cause mortality in incident haemodialysis patients. Selvarajah V, Pasea L, Ojha S, Wilkinson IB, Tomlinson LA. PLoS One. 2014 Jan 28;9(1):e86514.
Central blood pressure: current evidence and clinical importance. McEniery CM, Cockcroft JR, Roman MJ, Franklin SS, Wilkinson IB. Eur Heart J. 2014 Jul;35(26):1719-25.
Effect of A Reduction in glomerular filtration rate after NEphrectomy on arterial STiffness and central hemodynamics: rationale and design of the EARNEST study. Moody WE, Tomlinson LA, Ferro CJ, Steeds RP, Mark PB, Zehnder D, Tomson CR, Cockcroft JR, Wilkinson IB, Townend JN. Am Heart J. 2014 Feb;167(2):141-149.e2.
A longitudinal study of maternal cardiovascular function from preconception to the postpartum period. Mahendru AA, Everett TR, Wilkinson IB, Lees CC, McEniery CM. J Hypertens. 2014 Apr;32(4):849-56.
Estimation of aortic pulse pressure using Fourier velocity encoded M-mode MR. Taviani V, Hickson SS, Hardy CJ, Patterson AJ, Young VE, McEniery CM, Wilkinson IB, Gillard JH, Graves MJ. J Magn Reson Imaging. 2014 Jan;39(1):85-93.
The nitric oxide pathway and possible therapeutic options in pre-eclampsia. Johal T, Lees CC, Everett TR, Wilkinson IB. Br J Clin Pharmacol. 2014 Aug;78(2):244-57.
Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, Boutouyrie P, Cameron J, Chen CH, Cruickshank JK, Hwang SJ, Lakatta EG, Laurent S, Maldonado J, Mitchell GF, Najjar SS, Newman AB, Ohishi M, Pannier B, Pereira T, Vasan RS, Shokawa T, Sutton-Tyrell K, Verbeke F, Wang KL, Webb DJ, Willum Hansen T, Zoungas S, McEniery CM, Cockcroft JR, Wilkinson IB. J Am Coll Cardiol. 2014 Feb 25;63(7):636-46.
More publications are available through PubMed.
