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Cambridge Cardiovascular




My research interests are in meta-analysis and evidence synthesis, clinical trial methodology, health economic evaluation, Mendelian randomisation methods, and cardiovascular epidemiology. 

I have collaborated on a number of major clinical trials, recently including all the major UK national trials of screening and treatment for abdominal aortic aneurysms (AAA).


Key publications: 

Lessons learned about prevalence and growth rates of abdominal aortic aneurysms from a 25-year ultrasound population screening programme. Oliver-Williams C, Sweeting MJ, Turton G, Parkin D, Cooper D, Rodd C, Thompson SG, Earnshaw JJ; Gloucestershire and Swindon Abdominal Aortic Aneurysm Screening Programme. Br J Surg. 2018 Jan;105(1):68-74.

Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors. Di Angelantonio E, Thompson SG, Kaptoge S, Moore C, Walker M, Armitage J, Ouwehand WH, Roberts DJ, Danesh J; INTERVAL Trial Group. Lancet. 2017 Nov 25;390(10110):2360-2371.

Interpreting findings from Mendelian randomization using the MR-Egger method. Burgess S, Thompson SG. Eur J Epidemiol. 2017 May;32(5):377-389.

Morphological suitability for endovascular repair, non-intervention rates, and operative mortality in women and men assessed for intact abdominal aortic aneurysm repair: systematic reviews with meta-analysis. Ulug P, Sweeting MJ, von Allmen RS, Thompson SG, Powell JT; SWAN collaborators. Lancet. 2017 Jun 24;389(10088):2482-2491.

Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles. Gregson JM, Freitag DF, Surendran P, Stitziel NO, Chowdhury R, Burgess S, Kaptoge S, Gao P, Staley JR, Willeit P, Nielsen SF, Caslake M, Trompet S, Polfus LM, Kuulasmaa K, Kontto J, Perola M, Blankenberg S, Veronesi G, Gianfagna F, Männistö S, Kimura A, Lin H, Reilly DF, Gorski M, Mijatovic V; CKDGen consortium, Munroe PB, Ehret GB; International Consortium for Blood Pressure, Thompson A, Uria-Nickelsen M, Malarstig A, Dehghan A; CHARGE inflammation working group, Vogt TF, Sasaoka T, Takeuchi F, Kato N, Yamada Y, Kee F, Müller-Nurasyid M, Ferrières J, Arveiler D, Amouyel P, Salomaa V, Boerwinkle E, Thompson SG, Ford I, Wouter Jukema J, Sattar N, Packard CJ, Shafi Majumder AA, Alam DS, Deloukas P, Schunkert H, Samani NJ, Kathiresan S; MICAD Exome consortium, Nordestgaard BG, Saleheen D, Howson JM, Di Angelantonio E, Butterworth AS, Danesh J; EPIC-CVD consortium and the CHD Exome+ consortium. Eur J Prev Cardiol. 2017 Mar;24(5):492-504.

Bias due to participant overlap in two-sample Mendelian randomization. Burgess S, Davies NM, Thompson SG. Genet Epidemiol. 2016 Nov;40(7):597-608.

Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants. Burgess S, Bowden J, Fall T, Ingelsson E, Thompson SG. Epidemiology. 2017 Jan;28(1):30-42.

The use of repeated blood pressure measures for cardiovascular risk prediction: a comparison of statistical models in the ARIC study. Sweeting MJ, Barrett JK, Thompson SG, Wood AM. Stat Med. 2017 Dec 10;36(28):4514-4528.

Recruitment and representativeness of blood donors in the INTERVAL randomised trial assessing varying inter-donation intervals. Moore C, Bolton T, Walker M, Kaptoge S, Allen D, Daynes M, Mehenny S, Sambrook J, Watkins NA, Miflin G, Di Angelantonio E, Ouwehand WH, Roberts DJ, Danesh J, Thompson SG. Trials. 2016 Sep 20;17(1):458.

Parity, breastfeeding and risk of coronary heart disease: A pan-European case-cohort study. Peters SA, van der Schouw YT, Wood AM, Sweeting MJ, Moons KG, Weiderpass E, Arriola L, Benetou V, Boeing H, Bonnet F, Butt ST, Clavel-Chapelon F, Drake I, Gavrila D, Key TJ, Klinaki E, Krogh V, Kühn T, Lassale C, Masala G, Matullo G, Merritt M, Molina-Portillo E, Moreno-Iribas C, Nøst TH, Olsen A, Onland-Moret NC, Overvad K, Panico S, Redondo ML, Tjønneland A, Trichopoulou A, Tumino R, Turzanski-Fortner R, Tzoulaki I, Wennberg P, Winkvist A, Thompson SG, Di Angelantonio E, Riboli E, Wareham NJ, Danesh J, Butterworth AS. Eur J Prev Cardiol. 2016 Nov;23(16):1755-1765.

More publications are available through PubMed.

Director of Research in Biostatistics
Fellow of the Academy of Medical Sciences
Professor Simon  Thompson