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Cambridge Cardiovascular



My team aims to understand the mechanisms through which alterations in vascular cell function contribute to vascular disease and transplant rejection.

We focus on the role of tumour necrosis factor (TNF) in renal and cardiovascular disease, and how the two distinct receptors for TNF are independently regulated and mediate different cellular responses.


Key publications: 

TL1-A can engage death receptor-3 and activate NF-kappa B in endothelial cells. Wang J, Al-Lamki RS, Zhu X, Liu H, Pober JS, Bradley JR. BMC Nephrol. 2014 Nov 16;15(1):178.

In vitro self-assembly of human pericyte-supported endothelial microvessels in three-dimensional coculture: a simple model for interrogating endothelial-pericyte interactions. Waters JP, Kluger MS, Graham M, Chang WG, Bradley JR, Pober JS. J Vasc Res. 2013;50(4):324-31.

TNF, acting through inducibly expressed TNFR2, drives activation and cell cycle entry of c-Kit+ cardiac stem cells in ischemic heart disease. Al-Lamki RS, Lu W, Wang J, Yang J, Sargeant TJ, Wells R, Suo C, Wright P, Goddard M, Huang Q, Lebastchi AH, Tellides G, Huang Y, Min W, Pober JS, Bradley JR. Stem Cells. 2013 Sep;31(9):1881-92.

Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. Paul DS, Albers CA, Rendon A, Voss K, Stephens J; HaemGen Consortium, van der Harst P, Chambers JC, Soranzo N, Ouwehand WH, Deloukas P. Genome Res. 2013 Jul;23(7):1130-41.