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Cambridge Cardiovascular



Coronary stent safety; Cardioprotection during PCI; Metabolic optimisation during PCI; Myocardial injury during revascularization; Coronary/left ventricular physiological assessment during PCI; Coronary microvascular and collateral function assessment during PCI; Vulnerable plaque imaging with VH-IVUS and OCT; Biomarker profiling during PCI; Coronary intervention risk prediction modeling; Coronary stent design & technology; Innovation of interventional devices; PFO closure in sleep apneoa; Right ventricular haemodynamics


Key publications: 

Intravascular ultrasound of the proximal left anterior descending artery is sufficient to detect early cardiac allograft vasculopathy. Floré V, Brown AJ, Pettit SJ, West NEJ, Lewis C, Parameshwar J, Hoole SP. Clin Transplant. 2018 Feb;32(2).

Effects of Patent Foramen Ovale Closure on Obstructive Sleep Apnea Syndrome: PCOSA Study. Hoole SP, Hernández-Sánchez J, Davies WR, McNab DC, Calvert PA, Rana BS, Shapiro LM, Davies MG. Can J Cardiol. 2017 Dec;33(12):1708-1715.

Prediction of postpercutaneous coronary intervention myocardial infarction: insights from intravascular imaging, coronary flow, and biomarker evaluation. Hoole SP, Hernández-Sánchez J, Brown AJ, Giblett JP, Bennett MR, West NEJ. Coron Artery Dis. 2018 May;29(3):246-253.

Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study. Escaned J, Collet C, Ryan N, De Maria GL, Walsh S, Sabate M, Davies J, Lesiak M, Moreno R, Cruz-Gonzalez I, Hoole SP, Ej West N, Piek JJ, Zaman A, Fath-Ordoubadi F, Stables RH, Appleby C, van Mieghem N, van Geuns RJ, Uren N, Zueco J, Buszman P, Iñiguez A, Goicolea J, Hildick-Smith D, Ochala A, Dudek D, Hanratty C, Cavalcante R, Kappetein AP, Taggart DP, van Es GA, Morel MA, de Vries T, Onuma Y, Farooq V, Serruys PW, Banning AP. Eur Heart J. 2017 Nov 7;38(42):3124-3134.

Anatomical plaque and vessel characteristics are associated with hemodynamic indices including fractional flow reserve and coronary flow reserve: A prospective exploratory intravascular ultrasound analysis. Brown AJ, Giblett JP, Bennett MR, West NEJ, Hoole SP. Int J Cardiol. 2017 Dec 1;248:92-96.

Plaque Rupture in Coronary Atherosclerosis Is Associated With Increased Plaque Structural Stress. Costopoulos C, Huang Y, Brown AJ, Calvert PA, Hoole SP, West NEJ, Gillard JH, Teng Z, Bennett MR. JACC Cardiovasc Imaging. 2017 Dec;10(12):1472-1483.

Stunning and Right Ventricular Dysfunction Is Induced by Coronary Balloon Occlusion and Rapid Pacing in Humans: Insights From Right Ventricular Conductance Catheter Studies. Axell RG, Giblett JP, White PA, Klein A, Hampton-Til J, O'Sullivan M, Braganza D, Davies WR, West NEJ, Densem CG, Hoole SP. J Am Heart Assoc. 2017 Jun 6;6(6).

Ventriculo-arterial coupling detects occult RV dysfunction in chronic thromboembolic pulmonary vascular disease. Axell RG, Messer SJ, White PA, McCabe C, Priest A, Statopoulou T, Drozdzynska M, Viscasillas J, Hinchy EC, Hampton-Till J, Alibhai HI, Morrell N, Pepke-Zaba J, Large SR, Hoole SP. Physiol Rep. 2017 Apr;5(7).

Early disarticulation of a bioresorbable vascular scaffold: an underreported consequence of repeat imaging. Giblett JP, Brown AJ, Hoole SP, West NEJ. Cardiovasc Interv Ther. 2018 Apr;33(2):175-177.

Rapid Pacing-Induced Right Ventricular Dysfunction Is Evident After Balloon-Expandable Transfemoral Aortic Valve Replacement. Axell RG, White PA, Giblett JP, Williams L, Rana BS, Klein A, O'Sullivan M, Davies WR, Densem CG, Hoole SP. J Am Coll Cardiol. 2017 Feb 21;69(7):903-904.

Implantation of bioresorbable vascular scaffolds following acute coronary syndrome is associated with reduced early neointimal growth and strut coverage. Giblett JP, Brown AJ, Keevil H, Jaworski C, Hoole SP, West NE. EuroIntervention. 2016 Aug 20;12(6):724-33.

Diastolic Backward-Traveling Decompression (Suction) Wave Correlates With Simultaneously Acquired Indices of Diastolic Function and Is Reduced in Left Ventricular Stunning. Ladwiniec A, White PA, Nijjer SS, O'Sullivan M, West NE, Davies JE, Hoole SP. Circ Cardiovasc Interv. 2016 Sep;9(9).

Glucagon-like peptide-1 derived cardioprotection does not utilize a KATP-channel dependent pathway: mechanistic insights from human supply and demand ischemia studies. Giblett JP, Axell RG, White PA, Clarke SJ, McCormick L, Read PA, Reinhold J, Brown AJ, O'Sullivan M, West NE, Dutka DP, Hoole SP. Cardiovasc Diabetol. 2016 Jul 19;15:99.

More publications available through PubMed.