Dr Tian Zhao

Research

I am a BHF Clinical Lecturer in Cardiovascular Medicine and Cardiology Registrar sub-specialising in interventional cardiology. I have an MPhil in Translation Medicine and Therapeutics. For my PhD, I completed two early phase clinical trials on immuno-modulation in patients with myocardial infarction, targeting the adaptive immune system using low-dose interleukin-2 and rituximab separately. Currently, both therapies have been taken into phase 2b trials.

My ongoing research interests are in translational, experimental medicine trials looking at immuno-modulation in cardiovascular diseases.

Publication (Symplectic Elements)

Journal articles

2022

Zhao, TX., Sriranjan, RS., Tuong, ZK., Lu, Y., Sage, AP., Nus, M., Hubsch, A., Kaloyirou, F., Vamvaka, E., Helmy, J., Kostapanos, M., Jalaludeen, N., Klatzmann, D., Tedgui, A., Rudd, JHF., Horton, SJ., Huntly, BJP., Hoole, SP., Bond, SP., Clatworthy, MR., Cheriyan, J. and Mallat, Z., 2022. Regulatory T-Cell Response to Low-Dose Interleukin-2 in Ischemic Heart Disease NEJM Evidence, v. 1
Doi: 10.1056/evidoa2100009

Zhao, TX., Aetesam-Ur-Rahman, M., Sage, AP., Victor, S., Kurian, R., Fielding, S., Ait-Oufella, H., Chiu, Y-D., Binder, CJ., Mckie, M., Hoole, SP. and Mallat, Z., 2022. Rituximab in patients with acute ST-elevation myocardial infarction: an experimental medicine safety study. Cardiovasc Res, v. 118
Doi: http://doi.org/10.1093/cvr/cvab113

2021 (Accepted for publication)

Zhao, TX., Sriranjan, R., Tuong, Z., Lu, Y., Sage, A., Nus, M., Hubsch, A., Kaloyirou, F., Vamvaka, E., Helmy, J., Kostapanos, M., Jalaludeen, N., Klatzmann, D., Tedgui, A., Rudd, J., Horton, S., Huntly, B., Hoole, S., Bond, S., Clatworthy, M., Cheriyan, J. and Mallat, Z., 2021 (Accepted for publication). Regulatory T-Cell Response to Low-Dose Interleukin-2 in Ischemic Heart Disease New England Journal of Medicine Evidence,
Doi: 10.1056/EVIDoa2100009

2021

Yu, X., Newland, SA., Zhao, TX., Lu, Y., Sage, AS., Sun, Y., Sriranjan, RS., Ma, MKL., Lam, BYH., Nus, M., Harrison, JE., Bond, SJ., Cheng, X., Silvestre, J-S., Rudd, JHF., Cheriyan, J. and Mallat, Z., 2021. Innate Lymphoid Cells Promote Recovery of Ventricular Function After Myocardial Infarction. J Am Coll Cardiol, v. 78
Doi: 10.1016/j.jacc.2021.07.018

Aetesam-Ur-Rahman, M., Brown, AJ., Jaworski, C., Giblett, JP., Zhao, TX., Braganza, DM., Clarke, SC., Agrawal, BSK., Bennett, MR., West, NEJ. and Hoole, SP., 2021. Adenosine-Induced Coronary Steal Is Observed in Patients Presenting With ST-Segment-Elevation Myocardial Infarction. J Am Heart Assoc, v. 10
Doi: http://doi.org/10.1161/JAHA.120.019899

Aetesam-Ur-Rahman, M., Giblett, JP., Khialani, B., Kyranis, S., Clarke, SJ., Zhao, TX., Braganza, DM., Clarke, SC., West, NEJ., Bennett, MR. and Hoole, SP., 2021. GLP-1 vasodilatation in humans with coronary artery disease is not adenosine mediated. BMC Cardiovasc Disord, v. 21
Doi: http://doi.org/10.1186/s12872-021-02030-5

2020

Nus, M., Basatemur, G., Galan, M., Cros-Brunsó, L., Zhao, TX., Masters, L., Harrison, J., Figg, N., Tsiantoulas, D., Geissmann, F., Binder, CJ., Sage, AP. and Mallat, Z., 2020. NR4A1 Deletion in Marginal Zone B Cells Exacerbates Atherosclerosis in Mice-Brief Report. Arterioscler Thromb Vasc Biol, v. 40
Doi: 10.1161/ATVBAHA.120.314607

Zhao, TX., Newland, SA. and Mallat, Z., 2020. 2019 ATVB Plenary Lecture: Interleukin-2 Therapy in Cardiovascular Disease: The Potential to Regulate Innate and Adaptive Immunity. Arterioscler Thromb Vasc Biol, v. 40
Doi: 10.1161/ATVBAHA.119.312287

2019

Zhao, TX. and Mallat, Z., 2019. Targeting the Immune System in Atherosclerosis: JACC State-of-the-Art Review. J Am Coll Cardiol, v. 73
Doi: http://doi.org/10.1016/j.jacc.2018.12.083

Giblett, JP., Clarke, S., Zhao, T., McCormick, LM., Braganza, DM., Densem, CG., O'Sullivan, M., Adlam, D., Clarke, SC., Steele, J., Fielding, S., West, NEJ., Villar, SS. and Hoole, SP., 2019. The role of Glucagon-Like Peptide 1 Loading on periprocedural myocardial infarction During elective PCI (GOLD-PCI study): A randomized, placebo-controlled trial American Heart Journal, v. 215
Doi: http://doi.org/10.1016/j.ahj.2019.05.013

2018

Zhao, TX., Kostapanos, M., Griffiths, C., Arbon, EL., Hubsch, A., Kaloyirou, F., Helmy, J., Hoole, SP., Rudd, JHF., Wood, G., Burling, K., Bond, S., Cheriyan, J. and Mallat, Z., 2018. Low-dose interleukin-2 in patients with stable ischaemic heart disease and acute coronary syndromes (LILACS): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase I/II clinical trial. BMJ Open, v. 8
Doi: 10.1136/bmjopen-2018-022452

Clarke, SJ., Giblett, JP., Yang, LL., Hubsch, A., Zhao, T., Aetesam-Ur-Rahman, M., West, NEJ., O'Sullivan, M., Figg, N., Bennett, M., Wewer Albrechtsen, NJ., Deacon, CF., Cheriyan, J. and Hoole, SP., 2018. GLP-1 Is a Coronary Artery Vasodilator in Humans. J Am Heart Assoc, v. 7
Doi: 10.1161/JAHA.118.010321

2011

Holtzman, T., Sivam, V., Zhao, T., Frey, O., van der Wal, PD., de Rooij, NF., Dalley, JW. and Edgley, SA., 2011. Multiple extra-synaptic spillover mechanisms regulate prolonged activity in cerebellar Golgi cell-granule cell loops. J Physiol, v. 589
Doi: http://doi.org/10.1113/jphysiol.2011.207167

Theses / dissertations

2020 (No publication date)

Zhao, TX., 2020 (No publication date). PHARMACOLOGICAL MODULATION OF THE ADAPTIVE IMMUNE SYSTEM IN ISCHAEMIC HEART DISEASE
Doi: 10.17863/CAM.55391

Conference proceedings

2020

Zhao, TX., Sriranjan, RS., Lu, Y., Hubsch, A., Kaloyirou, F., Vamvaka, E., Helmy, J., Kostapanos, M., Klatzmann, D., Tedgui, A., Rudd, JHF., Hooles, SP., Bond, SP., Maga, Z. and Cheriyan, J., 2020. Low dose interleukin-2 in patients with stable ischaemic heart disease and acute coronary syndrome (LILACS) EUROPEAN HEART JOURNAL, v. 41

2018

Aetesam-ur-Rahman, M., Zhao, T., Giblett, J., Braganza, D., Clarke, S., Bennett, M., West, N. and Hoole, S., 2018. Instability of Coronary Flow Velocity and Basal Microvascular Resistance does not Affect Reproducibility of iFR Post- PCI. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, v. 72
Doi: http://doi.org/10.1016/j.jacc.2018.08.1634

Hoole, SP., Clarke, S., Giblett, J., Aetesam-ur-Rahman, M., Zhao, T., West, N. and Cheriyan, J., 2018. GLUCAGON-LIKE PEPTIDE-1 (GLP-1) HAS NO EFFECT ON PERIPHERAL VASODILATATION BUT AUGMENTS CORONARY MICROCIRCULATORY FLOW IN HUMANS JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, v. 71
Doi: http://doi.org/10.1016/S0735-1097(18)30561-8

Basatemur, G., Ackers-Johnson, M., Schoonejans, J., Kazachenka, A., Lam, B., Ma, M., Brimpari, M., Patel, M., Saleh, N., Murphy, D., Zhao, T., Yeo, G., Ferguson-Smith, A., Vallier, L., Sinha, S. and Mallat, Z., 2018. THE CHR9P21 RISK LOCUS AFFECTS IL-1/TLR SIGNALLING IN VSMC HEART, v. 104
Doi: http://doi.org/10.1136/heartjnl-2018-BCS.128

BHF Clinical Lecturer in Cardiovascular Medicine